Daily Archives: July 27, 2009
Although macrophages (MΦ) are known as essential players in wound healing, their contribution to recovery from spinal cord injury (SCI) is a subject of debate. The difficulties in distinguishing between different MΦ subpopulations at the lesion site have further contributed to the controversy and led to the common view of MΦ as functionally homogenous. Given the massive accumulation in the injured spinal cord of activated resident microglia, which are the native immune occupants of the central nervous system (CNS), the recruitment of additional infiltrating monocytes from the peripheral blood seems puzzling. A key question that remains is whether the infiltrating monocyte-derived MΦ contribute to repair, or represent an unavoidable detrimental response. The hypothesis of the current study is that a specific population of infiltrating monocyte-derived MΦ is functionally distinct from the inflammatory resident microglia and is essential for recovery from SCI.
19 years ago I was in a car accident and suffered a spinal cord injury rendering me quadriplegic. I’m facing tough challenges now and need support! Thank you for watching!
WASHINGTON – A common and safe blue food dye might provide the best treatment available so far for spinal cord injuries, U.S. researchers reported on Monday.
Tests in rats showed the dye, called brilliant blue G, a close relative of the common food dye Blue no. 1, crossed into the spinal fluid and helped block inflammation, Maiken Nedergaard of the University of Rochester Medical Center and colleagues reported.
“We have no effective treatment now for patients who have an acute spinal cord injury,” Dr. Steven Goldman, who worked on the study, said in a statement.