Wednesday, February 26, 2020

Tag: Ctgf protein

Scientists find key protein for spinal cord repair

Published: November 3, 2016

zebrafish-regenerating-spinal-cordsHealing protein bridges severed tissue in fish

A freshwater zebrafish costs less than two bucks at the pet store, but it can do something priceless: Its spinal cord can heal completely after being severed, a paralyzing and often fatal injury for humans.

While watching these fish repair their own spinal cord injuries, Duke University scientists have found a particular protein important for the process. Their study, published Nov. 4 in the journal Science, could generate new leads into tissue repair in humans.

Do Zebrafish Hold an Ingredient to Heal Spinal Cord Injuries?

Published: November 2, 2016

do-zebrafish-heal-spinal-cord-injuriesResearchers have identified a protein in zebrafish that plays a role in helping heal major spinal cord injuries. The results, published in the 4 November issue of Science, could provide an important clue for researchers looking for ways to facilitate similar tissue repair in humans.

While mammals lack the ability to regenerate nervous system tissue after spinal cord injury, zebrafish can regenerate such tissue. The mechanisms behind this recovery have remained elusive.

“Only six to eight weeks after a paralyzing injury that completely severs their spinal cord, zebrafish form new neurons, regrow axons and recover the ability to swim. Importantly, these regenerative events proceed without massive scarring,” explained Mayssa Mokalled of Duke University, a researcher involved in the study.

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