Tag: Wyss Center
With the help of robot-assisted rehabilitation and electrochemical spinal cord stimulation, rats with clinically relevant spinal cord injuries regained control of their otherwise paralyzed limbs. But how do brain commands for walking, swimming and stair-climbing bypass the injury and still reach the spinal cord to execute these complex tasks? EPFL scientists have observed for the first time that the brain reroutes task-specific motor commands through alternative pathways originating in the brainstem and projecting to the spinal cord. The therapy triggers the growth of new connections from the motor cortex into the brainstem and from the brainstem into the spinal cord, thus reconnecting the brain with the spinal cord below the injury. The results are published in Nature Neuroscience March 19th.
Spinal cord repair and rehabilitation is a difficult but important topic to research, can you please give a brief overview of research in this field?
There are many grades of spinal cord injuries, in terms of range of movement, from small disabilities to becoming wheelchair bound for the rest of your life, the range is very broad.
There are many different approaches to try to overcome these disabilities, with key areas of research being focussed on developing stem cell therapies and using growth factors to promote regrowth of the nerve tissue after the injury.