Wednesday, February 26, 2020

Tag: acrolein

An old drug with new potential: WWII chemical-weapon antidote shows early promise as treatment...

Published: March 28, 2017

WEST LAFAYETTE, Ind. – A drug developed during World War II as an antidote for a chemical warfare agent has been found to be effective at suppressing a neurotoxin that worsens the pain and severity of spinal cord injuries, suggesting a new tool to treat the injuries.

The neurotoxin, called acrolein, is produced within the body after nerve cells are damaged, increasing pain and triggering a cascade of biochemical events thought to worsen the injury’s severity.

Study points to potential monitoring approach for personalized treatment of spinal cord injuries

Published: December 8, 2016

Researchers have developed a urine test revealing the presence of a neurotoxin that likely worsens the severity and pain of spinal cord injuries, suggesting a new tool to treat the injuries.

The neurotoxin, called , is produced within the body after nerve cells are damaged, increasing pain and triggering a cascade of biochemical events thought to worsen the injury’s severity.

Drug may reduce chronic pain for spinal cord injuries

Published: October 29, 2013

West Lafayette, Indiana – Researchers have discovered that a known neurotoxin may cause chronic pain in people who suffer from paralysis, and a drug that has been shown to remove the toxin might be used to treat the pain.

The toxin, called acrolein, is produced in the body after nerve cells are injured, triggering a cascade of biochemical events thought to worsen the injury’s severity.

Testing method promising for spinal cord injuries, multiple sclerosis

Published: June 13, 2013

WEST LAFAYETTE, Ind. – A medical test previously developed to measure a toxin found in tobacco smokers has been adapted to measure the same toxin in people suffering from spinal cord injuries and multiple sclerosis, offering a potential tool to reduce symptoms.

The toxin, called acrolein, is produced in the body after nerve cells are injured, triggering a cascade of biochemical events thought to worsen the injury’s severity.

Purdue researchers work on drug to relieve spinal cord injuries

Published: April 26, 2006

Purdue University researchers are working to develop a drug that could reverse some spinal cord injuries as well as other neurological traumas.

Richard Borgens, founder of the Center for Paralysis Research and a leader of the team, said the team got the idea for the new drug after discovering that a blood pressure medication called hydralazine can act as an antidote to acrolein, a poison that damaged nerve cells release to destroy themselves.

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