Tag: Case Western Reserve University
A systemically injectable peptide, which may make it possible to restore lost functions in spinal cord injury patients, is moving toward clinical trials in early 2020.
The treatment, which was developed by Jerry Silver, a professor of neurosciences at Case Western Reserve University’s School of Medicine and advisor for NervGen Pharma, is the culmination of decades of work, and in pre-clinical studies, it has shown robust results in animal models.
Injuries to the spinal cord can cause permanent paralysis and even lead to death, with little to no hope of regaining lost functions once the trauma has occurred.
Dr Jerry Silver and his team at Case Western Reserve University Medical School, USA, have been working to understand why nerves that are damaged through spinal injury don’t regenerate and to identify non-invasive, easy to administer strategies that can promote robust functional recovery.
Case Western Reserve Researchers Restore Breathing and Partial Forelimb Function in Rats with Chronic...
Promising results provide hope for humans suffering from chronic paralysis
Millions of people worldwide are living with chronic spinal cord injuries, with 250,000 to 500,000 new cases each year—most from vehicle crashes or falls. The most severe spinal cord injuries completely paralyze their victims and more than half impair a person’s ability to breathe. Now, a breakthrough study published in Nature Communications has demonstrated, in animal models of chronic injury, that long-term, devastating effects of spinal cord trauma on breathing and limb function may be reversible.
For a brain-computer interface (BCI) to be truly useful for a person with tetraplegia, it should be ready whenever it’s needed, with minimal expert intervention, including the very first time it’s used. In a new study in the Journal of Neural Engineering, researchers in the BrainGate collaboration demonstrate new techniques that allowed three participants to achieve peak BCI performance within three minutes of engaging in an easy, one-step process.
One participant, “T5,” a 63-year-old man who had never used a BCI before, needed only 37 seconds of calibration time before he could control a computer cursor to reach targets on a screen, just by imagining using his hand to move a joystick.
Bottom Line: A team of neuroscientists has uncovered a neural network that can restore diaphragm function after spinal cord injury. The network allows the diaphragm to contract without input from the brain, which could help paralyzed spinal cord injury patients breathe without a respirator.
Journal in Which the Study was Published: Cell Reports
Author: Jared Cregg, Neurosciences graduate student at Case Western Reserve University School of Medicine in Cleveland, Ohio is first author on the study.