Saturday, October 19, 2019

Tag: immune response

Nanoparticles promote functional healing following spinal cord injury

Published: July 24, 2019

Novel approach also shows promise for autoimmune diseases

Paralyzing damage in spinal cord injury (SCI) is often caused by the zealous immune response to the injury. NIBIB-funded engineers have developed nanoparticles that lure immune cells away from the spinal cord, allowing regeneration that restored spinal cord function in mice.

An ‘EpiPen’ for spinal cord injuries

Published: July 11, 2019

ANN ARBOR—An injection of nanoparticles can prevent the body’s immune system from overreacting to trauma, potentially preventing some spinal cord injuries from resulting in paralysis.

The approach was demonstrated in mice at the University of Michigan, with the nanoparticles enhancing healing by reprogramming the aggressive immune cells—call it an “EpiPen” for trauma to the central nervous system, which includes the brain and spinal cord.

Spinal injuries throw body clocks off-schedule, new study shows

Published: December 3, 2018

Spinal injuries throw body clocks off-scheduleIn the hours and days following a spinal cord injury, the gears that control the body’s internal clocks fall profoundly out of sync, impacting body temperature, hormone fluctuation, immunity and the timing of a host of other bodily processes, according to new CU Boulder research.

The study, funded by the U.S. Department of Defense and published Monday in the journal eNeuro, is among the first to comprehensively assess how spinal injury impacts circadian rhythms, or the 24-hour-cycles of physiological processes. If replicated in humans, the findings could lead to new “chronotherapies” to reset off-kilter clocks and potentially improve long-term recovery.

Immune cells could hold key to therapies for spinal cord injuries

Published: November 7, 2018

Fresh insights into how Zebrafish repair their damaged nerve connections could aid the development of therapies for people with spinal cord injuries.

Scientists have found the immune system plays a key role in helping Zebrafish nerve cells to regenerate after injury.

The findings offer clues for developing treatments that could one day help people to regain movement after spinal cord injury.

What is Sepsis?

Published: October 3, 2017

Sepsis is a life threatening medical condition that arises when the body’s attempt to fight an infection results in the immune system damaging tissues and organs.

Ohio State Scientists Explain How Gut Microbes Change After Spinal Cord Injury

Published: October 17, 2016

pop-phillipCOLUMBUS, Ohio – The community of bacteria that live in our intestines, also called the “gut microbiome,” is important to normal intestinal function. Knowing that spinal cord injuries often negatively affect the gut’s ability to do its job, researchers at The Ohio State University Wexner Medical Center showed that spinal cord injury causes profound changes in the gut microbiota. They also showed that feeding mice probiotics after a spinal cord injury confers neuroprotection and improves functional recovery.

The findings are published online today in the Journal of Experimental Medicine.

Spinal Cord Injury Causes ‘Immune System Paralysis’

Published: March 7, 2016

brain-oxfordjournals-coverCOLUMBUS, Ohio – New research led by The Ohio State University Wexner Medical Center is showing that spinal cord injuries can also cause a “paralysis” of the immune system that renders these patients more susceptible to pneumonia and other infections.

Findings of the study are published in the March issue of the journal Brain.

“Pneumonia is the leading cause of death after acute spinal cord injury and is associated with poor neurological outcome. Patients with spinal cord injuries are 37 times more likely to die of pneumonia than those without these injuries,”

Controlling Immune Response in Spinal Cord Injury Patients

Published: January 27, 2016

human's thoracic-lumbar spine and inflammation at spineThe immune system of spinal cord injury patients can be controlled using a family of therapeutic stem cells, according to findings published in Scientific Reports.

Researchers from Case Western Reserve University studied the therapeutic stem cells, known as multipotent adult progenitor cells (MAPC) in order to observe their qualities and effects on spinal cord injury patients’ immune systems.

Scientists discover trigger for protective immune response to spinal cord injuries

Published: February 5, 2015

Hot on the heels of discovering a protective form of immune response to spinal cord injury, researchers at the University of Virginia School of Medicine have pinpointed the biological trigger for that response – a vital step toward being able to harness the body’s defenses to improve treatment for spine injuries, brain trauma, Alzheimer’s disease and other neurodegenerative conditions.

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