Friday, September 18, 2020

Tag: Purdue University

An old drug with new potential: WWII chemical-weapon antidote shows early promise as treatment...

Published: March 28, 2017

WEST LAFAYETTE, Ind. – A drug developed during World War II as an antidote for a chemical warfare agent has been found to be effective at suppressing a neurotoxin that worsens the pain and severity of spinal cord injuries, suggesting a new tool to treat the injuries.

The neurotoxin, called acrolein, is produced within the body after nerve cells are damaged, increasing pain and triggering a cascade of biochemical events thought to worsen the injury’s severity.

Study points to potential monitoring approach for personalized treatment of spinal cord injuries

Published: December 8, 2016

Researchers have developed a urine test revealing the presence of a neurotoxin that likely worsens the severity and pain of spinal cord injuries, suggesting a new tool to treat the injuries.

The neurotoxin, called , is produced within the body after nerve cells are damaged, increasing pain and triggering a cascade of biochemical events thought to worsen the injury’s severity.

Testing method promising for spinal cord injuries, multiple sclerosis

Published: June 13, 2013

WEST LAFAYETTE, Ind. – A medical test previously developed to measure a toxin found in tobacco smokers has been adapted to measure the same toxin in people suffering from spinal cord injuries and multiple sclerosis, offering a potential tool to reduce symptoms.

The toxin, called acrolein, is produced in the body after nerve cells are injured, triggering a cascade of biochemical events thought to worsen the injury’s severity.

Researchers use nanoparticles to deliver treatment for brain, spinal cord injuries

Published: November 7, 2008

Purdue University researchers have developed a method of using nanoparticles to deliver treatments to injured brain and spinal cord cells.

A team led by Richard Borgens of the School of Veterinary Medicine’s Center for Paralysis Research and Welden School of Biomedical Engineering coated silica nanoparticles with a polymer to target and repair injured guinea pig spinal cords. That research is being published in the October edition of the journal Small.

The team then used the coated nanoparticles to deliver both the polymer and hydralazine to cells with secondary damage from a naturally produced toxin. That research was published in August by the journal Nanomedicine.

Purdue researchers work on drug to relieve spinal cord injuries

Published: April 26, 2006

Purdue University researchers are working to develop a drug that could reverse some spinal cord injuries as well as other neurological traumas.

Richard Borgens, founder of the Center for Paralysis Research and a leader of the team, said the team got the idea for the new drug after discovering that a blood pressure medication called hydralazine can act as an antidote to acrolein, a poison that damaged nerve cells release to destroy themselves.

Study on dogs yields hope in human paralysis treatment

Published: December 4, 2004

Researchers have successfully tested injections of a liquid polymer to heal spinal injuries in dogs in an experiment that also offers hope for preventing human paralysis.

The liquid, called polyethylene glycol (PEG), if administered within 72 hours of serious spinal injury, was able to prevent three out of four dogs in a test group from suffering permanent spinal damage.