Tag: Washington University
Humans can regenerate their peripheral nerves (PNS), but the regenerative ability does not extend to the central nervous system (CNS). So, what changed? Previously, the focus had been on identifying the cellular and molecular contributors that differentiate this regenerative ability in CNS vs. PNS. But now there seems to be a shift towards recognizing the underlying genetic makeup differences between the two.
Researchers at Washington University School of Medicine in St. Louis have identified some of the critical steps taken by peripheral nerves – those in the arms and legs – as they regenerate.
WashU students design prototype garments for athletes with disabilities
Rugby is hard-hitting, fast-moving and adrenaline-fueled. But for elite Paralympic wheelchair athletes, the sport also can pose particular challenges.
Innovative technique helps patients with neck injuries
A pioneering surgical technique has restored some hand and arm movement to patients immobilized by spinal cord injuries in the neck, reports a new study at Washington University School of Medicine in St. Louis.
Like railroad switchmen, the focus is on rerouting passageways; however, instead of trains on a track, the surgeons redirect peripheral nerves in a quadriplegic’s arms and hands by connecting healthy nerves to the injured nerves. Essentially, the new nerve network reintroduces conversation between the brain and the muscles that allows patients, once again, to accomplish tasks that foster independence, such as feeding themselves or writing with a pen.
Researchers at Washington University School of Medicine in St. Louis have identified a chain reaction that triggers the regrowth of some damaged nerve cell branches, a discovery that one day may help improve treatments for nerve injuries that can cause loss of sensation or paralysis.
The scientists also showed that nerve cells in the brain and spinal cord are missing a link in this chain reaction. The link, a protein called HDAC5, may help explain why these cells are unlikely to regrow lost branches on their own. The new research suggests that activating HDAC5 in the central nervous system may turn on regeneration of nerve cell branches in this region, where injuries often cause lasting paralysis.
Surgeons at Washington University School of Medicine in St. Louis have restored some hand function in a quadriplegic patient with a spinal cord injury at the C7 vertebra, the lowest bone in the neck. Instead of operating on the spine itself, the surgeons rerouted working nerves in the upper arms. These nerves still “talk” to the brain because they attach to the spine above the injury.
Following the surgery, performed at Barnes-Jewish Hospital, and one year of intensive physical therapy, the patient regained some hand function, specifically the ability to bend the thumb and index finger. He can now feed himself bite-size pieces of food and write with assistance.