Following spinal cord injury, most patients experience an exaggeration of muscle tone called spasticity, which frequently leads to physical disability.
A team at the Institut de Neurosciences de la Timone (CNRS/Aix-Marseille Université) has just identified one of the molecular mechanisms responsible for this phenomenon. It has also proposed two therapeutic solutions that have proved conclusive in animals, one of which will be tested during phase II clinical trials as early as this year. This work, published in Nature Medicineon 14 March 2016, thus opens new therapeutic avenues to reduce this physical disability.
Twelve million people throughout the world suffer from a motor disorder called spasticity. Continue Reading »