Tag: neural stem cells
Modern medicine has still not managed to crack the problem of spinal cord injuries that result in significant paralysis or loss of functional status.
There are numerous factors that influence the inability to restore movement or autonomous bodily control to these patients. A prominent example of these is the inability to cultivate new neurons that make up and power the spinal cord.
However, some researchers have claimed that they have successfully induced ‘generic’ human stem cells to differentiate into stem cells that apply more specifically to the spine.
Derived from human pluripotent stem cells, these diverse cells advance disease modeling and may provide new, scalable source of replacement cells for spinal cord injuries
Researchers at University of California San Diego School of Medicine report that they have successfully created spinal cord neural stem cells (NSCs) from human pluripotent stem cells (hPSCs) that differentiate into a diverse population of cells capable of dispersing throughout the spinal cord and can be maintained for long periods of time.
First-in-human clinical study found improved motor and sensory function in three of four participants
Writing in the June 1 issue of Cell Stem Cell, researchers at University of California San Diego School of Medicine report that a first-in-human phase I clinical trial in which neural stem cells were transplanted into participants with chronic spinal cord injuries produced measurable improvement in three of four subjects, with no serious adverse effects.
The molecule inhibits adult axon regeneration, but appears to stimulate young neurons
Recovery after severe spinal cord injury is notoriously fraught, with permanent paralysis often the result. In recent years, researchers have increasingly turned to stem cell-based therapies as a potential method for repairing and replacing damaged nerve cells. They have struggled, however, to overcome numerous innate barriers, including myelin, a mixture of insulating proteins and lipids that helps speed impulses through adult nerve fibers but also inhibits neuronal growth.
Louis Tontodonato’s hopes and dreams may well lie in a virtual coin flip, a digital roll of the dice.
Paralyzed from the neck down, the 20-year-old Naples, Fla., man has enrolled in the first clinical trial testing the ability of stem cells to repair spinal cord injuries and restore sensation and movement in quadriplegics. Early studies in animals and humans have had remarkable results, enabling patients to resume everyday tasks they thought had been lost forever. If those early effects are validated, the treatment has the potential to drastically improve the quality of life and independence of thousands of spinal cord injury patients.
Spinal cord injuries are extremely tragic, often leading to irreversible paralysis. Many groups around the world are pursuing various treatment options. Some of these attempt to transplant new neurons to repair the damage, use drugs to boost natural healing, or use electronic means to bridge the gap.
Currently it’s only in mice, but some researchers from China have produced extremely promising results using tissue engineering.