Monday, July 6, 2020

Tag: regenerative medicine

Regeneration of Neural Connections After Spinal Cord and Optic Nerve Damage

Published: May 5, 2020

Spinal cord injuries can have lasting and devastating effects on mobility and cognitive function due to permanent nerve cell damage or death. A new study from researchers at Temple University now shows how neuronal connections can be regenerated after such injuries.

Neurons contain structural appendages called axons which form connections with each other throughout the brain and greater parts of the body. These axons form an interconnected communication system that regulates sensory and motor functions; injury to axons can result in their breakage, leading to irreversible damage.

A common drug could help restore limb function after spinal cord injury

Published: December 3, 2019

In mouse study, nerve pain drug gabapentin promotes regeneration of neural circuits

Long-term treatment with gabapentin, a commonly prescribed drug for nerve pain, could help restore upper limb function after a spinal cord injury, new research in mice suggests.

In the study, mice treated with gabapentin regained roughly 60 percent of forelimb function in a skilled walking test, compared to restoration of approximately 30 percent of forelimb function in mice that received a placebo.

Japanese Researchers Will Use Stem Cells to Treat Spinal Cord Injuries in Groundbreaking Clinical...

Published: February 19, 2019

There could a new form of treatment in Japan for spinal cord injuries if a newly-approved clinical trial hits the mark.

On Monday, a special committee of the Ministry of Health, Labor and Welfare in Japan approved a clinical research program at Tokyo’s Keio University to use induced pluripotent stem (iPS) cells to treat spinal cord injuries. According to the Nikkei Asian Review, this is a groundbreaking first-of-its-kind study. The clinical trial is expected to begin this summer.

Spinal Neurons Grown From Stem Cells For First Time

Published: August 22, 2018

Modern medicine has still not managed to crack the problem of spinal cord injuries that result in significant paralysis or loss of functional status.

There are numerous factors that influence the inability to restore movement or autonomous bodily control to these patients. A prominent example of these is the inability to cultivate new neurons that make up and power the spinal cord.

However, some researchers have claimed that they have successfully induced ‘generic’ human stem cells to differentiate into stem cells that apply more specifically to the spine.

Researchers Turn Skin Cells into Motor Neurons Without Using Stem Cells

Published: September 7, 2017

Cellular Renovation

Why build something from the ground up when one can just renovate an already existing structure? Essentially, that’s what researchers from the University of Washington School of Medicine in St. Louis had in mind when they developed a method for transforming adult human skin cells into motor neurons in a lab. They published their work in the journal Cell Stem Cell.

It’s Not a Rat’s Race for Human Stem Cells Grafted to Repair Spinal Cord...

Published: August 28, 2017

Lengthy study finds that implanted neural stem cells grow slow and steady, and success needs to be measured accordingly

More than one-and-a-half years after implantation, researchers at University of California San Diego School of Medicine and the San Diego Veterans Administration Medical Center report that human neural stem cells (NSCs) grafted into spinal cord injuries in laboratory rats displayed continued growth and maturity, with functional recovery beginning one year after grafting.

Engineer aims to grow spinal tissue in lab

Published: March 21, 2017

For a soldier who suffered a spinal cord injury on the battlefield, the promise of regenerative medicine is to fully repair the resulting limb paralysis. But that hope is still years from reality.

Not only powerful, but efficient. Studying diseases in lab-created tissue may help reduce the price tag — now roughly $1.8 billion — for bringing a new drug to market, which is one of the reasons Ashton received a National Science Foundation CAREER Award for advancing tissue engineering of the human spinal cord. During the project’s five-year funding period, his lab in the Wisconsin Institute for Discovery will fine-tune the technology for growing a neural tube, the developmental predecessor of the spinal cord, from scratch.

UCLA professor developing potential treatment for spinal cord injuries

Published: March 10, 2017

A UCLA professor is working to develop a treatment for spinal cord injuries, which are currently incurable.

Stephanie Seidlits, assistant professor of bioengineering, will attempt to use biomaterial made out of hyaluronic acid – a long chain of sugars in the body – to create a treatment that can be injected into spinal cords. Seidlits will conduct the research with students using a $500,000 grant she won March 1.

The prestigious CAREER award, granted by the National Science Foundation, aims to support scholars who effectively integrate research with education.

Generating improvement in spinal cord injuries

Published: January 24, 2017

Early clinical trial results announced offer new hope in regenerative medicine

A new therapy to treat spinal cord injuries in people who have lost all motor and sensory function below the injury site shows additional motor function improvement at 6-months and 9-months following treatment with 10 million AST-OPC1. The positive efficacy results from an ongoing research study were announced on Jan. 24 in a conference held by Asterias Biotherapeutics, Inc., the biotechnology company that manufactures AST-OPC1.

UT Southwestern Researchers Amplify Regeneration of Spinal Nerve Cells

Published: October 11, 2016

researchers-amplify-regeneration-of-spinal-nerve-cellsNewswise — DALLAS – Oct. 11, 2016 – UT Southwestern Medical Center researchers successfully boosted the regeneration of mature nerve cells in the spinal cords of adult mammals – an achievement that could one day translate into improved therapies for patients with spinal cord injuries.

“This research lays the groundwork for regenerative medicine for spinal cord injuries. We have uncovered critical molecular and cellular checkpoints in a pathway involved in the regeneration process that may be manipulated to boost nerve cell regeneration after a spinal injury,” said senior author Dr. Chun-Li Zhang, Associate Professor of Molecular Biology at UT Southwestern.