Tag: Spinal Cord Injury Research
Two top scientists at the University of Virginia School of Medicine are seeking answers to questions about spinal cord injuries that have long frustrated the development of effective treatments.
The scientists, Jonathan Kipnis, PhD, and Kodi Ravichandran, PhD, are teaming up to understand why critical nerve cells called neurons continue to die after spinal cord injuries. So little is known that doctors aren’t even certain if the body’s immune response is beneficial or harmful.
In experiments on rats with spinal cord injuries, the rodents improved their walking ability following treatment.
Researchers have demonstrated a novel method that might regrow nerve cells at the site of spinal injuries.
Recently researchers discovered an axon guidance protein known as Plexin B2 in the central nervous system (CNS). During the spinal cord injury, this protein plays a significant role in the healing of the wound and neural repair.
The experiment was designed and conducted by the Icahn School of Medicine at Mount Sinai. This study could help the development of the treatments or therapies which target axon guidance pathways for treating the patients of Spinal cord injury more effectively.
Here are six key updates in the treatment of spinal cord injuries in the past six months:
The Tim and Caroline Reynolds Center for Spinal Stimulation at Kessler Foundation opened in East Hanover, N.J., in January. The facility has more than 50 researchers focusing on spinal stimulation research and restoring function in people with paralysis. Gail Forrest, PhD, who specializes in applying electrical stimulation to spinal cord injury research, was appointed director of the center.
Permanent neurological impairments can occur after spinal cord injury (SCI) due to the failure of the spinal cord motor and sensory axons to regenerate.
This is because the mammalian central nervous system (CNS), unlike in some amphibians and reptiles, has inhibitory molecules blocking growth post-development, as well as the lack of an effective regenerative response system. Within the peripheral nervous system (PNS), there is some limited axonal recovery that can occur naturally.
Spinal cord injuries caused by accidents, violence and disease paralyze from the neck down more than 5,000 people every year. In the first few months after injury, some people regain some movement and sensation in their limbs. Those who do not show improvement in the first few months are unlikely to ever recover.
In mouse study, nerve pain drug gabapentin promotes regeneration of neural circuits
Long-term treatment with gabapentin, a commonly prescribed drug for nerve pain, could help restore upper limb function after a spinal cord injury, new research in mice suggests.
In the study, mice treated with gabapentin regained roughly 60 percent of forelimb function in a skilled walking test, compared to restoration of approximately 30 percent of forelimb function in mice that received a placebo.
A new study led by a University of Calgary researcher at the Cumming School of Medicine (CSM) finds that fatigue and sleep may need more attention in order to prevent issues like stroke after spinal cord injury.
“People with spinal cord injury have alarming rates of stroke, and we wanted to understand why,” says study lead Dr. Aaron Phillips, Ph.D., assistant professor, in the Department of Physiology & Pharmacology, and member of the CSM’s Libin Cardiovascular Institute of Alberta and the Hotchkiss Brain Institute.
The functional sophistication of the spinal cord can have devastating consequences. Will modern scientific developments replicate its functions?
The “central nervous system” delicately orchestrates the complex concerto of our mental and physical faculties, from perception through to action and all the intermediary processes in-between. Such functional sophistication is disturbed in spinal cord injury, which can have devastating short-term and long-term consequences, determined by the level and severity of the injury.
Polymerized estrogen shown to protect nervous system cells. Research could enable improved treatment of spinal cord injuries.
Spinal cord damage that causes paralysis and reduced mobility doesn’t always stop with the initial trauma, but there are few treatment options to halt increased deterioration — and there is no cure. Researchers at Rensselaer Polytechnic Institute have developed a promising new biomaterial that could offer targeted treatment to the damaged spinal cord and tissue, preventing further damage.