Tag: nerve cells
JNCASR researchers find out that it has the ability to reprogramme damaged nerve cells
A small molecule synthesised by researchers at the Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), in Bengaluru, may have the power to make patients paralysed by spinal cord injury walk again.
An international team of researchers who worked with the molecule demonstrated that it has the ability to reprogramme nerve cells damaged during a spinal cord injury in animals, recover sensory and motor functions.
Case Western Reserve Researchers Restore Breathing and Partial Forelimb Function in Rats with Chronic...
Promising results provide hope for humans suffering from chronic paralysis
Millions of people worldwide are living with chronic spinal cord injuries, with 250,000 to 500,000 new cases each year—most from vehicle crashes or falls. The most severe spinal cord injuries completely paralyze their victims and more than half impair a person’s ability to breathe. Now, a breakthrough study published in Nature Communications has demonstrated, in animal models of chronic injury, that long-term, devastating effects of spinal cord trauma on breathing and limb function may be reversible.
Scientists developing robust method to treat spinal cord injuries using nose cells
Researchers have designed a new way to grow nose cells in the lab heralding hope for sufferers of spinal cord injuries, including those who are wheelchair bound.
Griffith University’s Mr Mo Chen grew nose nerve cells in the lab, which can treat mice with spinal cord injuries.
The molecule inhibits adult axon regeneration, but appears to stimulate young neurons
Recovery after severe spinal cord injury is notoriously fraught, with permanent paralysis often the result. In recent years, researchers have increasingly turned to stem cell-based therapies as a potential method for repairing and replacing damaged nerve cells. They have struggled, however, to overcome numerous innate barriers, including myelin, a mixture of insulating proteins and lipids that helps speed impulses through adult nerve fibers but also inhibits neuronal growth.
Searching the entire genome, a Yale research team has identified a gene that when eliminated can spur regeneration of axons in nerve cells severed by spinal cord injury.
“For the first time, the limits on nerve fiber regeneration were studied in an unbiased way across nearly all genes,” said Stephen Strittmatter, the Vincent Coates Professor of Neurology and senior author of the study appearing April 10 in the journal Cell Reports. “We had no idea whether we knew a lot or a little about the mechanics of nerve cell regeneration.”
The healing ability of the central nervous system is very limited and injuries to the brain or spinal cord often result in permanent functional deficits. Researchers at Karolinska Institutet report in the scientific journal Cell that they have found an important mechanism that explains why this happens. Using this new knowledge, they were able to improve functional recovery following spinal cord injury in mice.
In many organs, damaged tissue can be repaired by generating new cells of the type that were lost.
Stem cell research is often controversial but it has also led to incredible medical progress in recent years.
Stem cell research is at defining moment. Although it can be controversial and does raise a lot of important ethical issues, this area of medical science has been characterised by a number of important advances, ever since the first embryonic stem cells were isolated from mice in the 1980s. In the near future, it could reshape the way we treat some of the world’s most debilitating diseases.
Stem cells have already been used as treatment for a number of years – think bone marrow transplant – and they have the potential to help with many other medical conditions.
Healing protein bridges severed tissue in fish
A freshwater zebrafish costs less than two bucks at the pet store, but it can do something priceless: Its spinal cord can heal completely after being severed, a paralyzing and often fatal injury for humans.
While watching these fish repair their own spinal cord injuries, Duke University scientists have found a particular protein important for the process. Their study, published Nov. 4 in the journal Science, could generate new leads into tissue repair in humans.
Newswise — DALLAS – Oct. 11, 2016 – UT Southwestern Medical Center researchers successfully boosted the regeneration of mature nerve cells in the spinal cords of adult mammals – an achievement that could one day translate into improved therapies for patients with spinal cord injuries.
“This research lays the groundwork for regenerative medicine for spinal cord injuries. We have uncovered critical molecular and cellular checkpoints in a pathway involved in the regeneration process that may be manipulated to boost nerve cell regeneration after a spinal injury,” said senior author Dr. Chun-Li Zhang, Associate Professor of Molecular Biology at UT Southwestern.
The spinal cord is often called as a delicate tissue, which is secured inside very hard vertebrae of spinal column. The spinal cord and brain is seen forming the central nervous system of our body. The spinal cord is basically made up of millions of nerve cells, which carry a number of signals to our brain and out over the other parts of human body. Unfortunately with issues like injuries with accident and with age or other ailments the spinal cord can end up getting injured. There are certain spinal cord injuries, which can be fixed with the help of treatment options like cell transplantation. Now, let us dig in deep into this treatment option in the following paragraphs: