JNCASR researchers find out that it has the ability to reprogramme damaged nerve cells
A small molecule synthesised by researchers at the Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), in Bengaluru, may have the power to make patients paralysed by spinal cord injury walk again.
An international team of researchers who worked with the molecule demonstrated that it has the ability to reprogramme nerve cells damaged during a spinal cord injury in animals, recover sensory and motor functions.
Humans can regenerate their peripheral nerves (PNS), but the regenerative ability does not extend to the central nervous system (CNS). So, what changed? Previously, the focus had been on identifying the cellular and molecular contributors that differentiate this regenerative ability in CNS vs. PNS. But now there seems to be a shift towards recognizing the underlying genetic makeup differences between the two.
Researchers at Washington University School of Medicine in St. Louis have identified some of the critical steps taken by peripheral nerves – those in the arms and legs – as they regenerate.
In a collaboration led by EPFL (Ecole polytechnique fédérale de Lausanne) in Switzerland and UCLA (University of California at Los Angeles) in the USA, scientists have now understood the underlying biological mechanisms required for severed nerve fibers to regenerate across complete spinal cord injury, bridging that gap in mice and rats for the first time.
The adult mammalian body has an incredible ability to heal itself in response to injury. Yet, injuries to the spinal cord lead to devastating conditions, since severed nerve fibers fail to regenerate in the central nervous system. Consequently, the brain’s electrical commands about body movement no longer reach the muscles, leading to complete and permanent paralysis.
The molecule inhibits adult axon regeneration, but appears to stimulate young neurons
Recovery after severe spinal cord injury is notoriously fraught, with permanent paralysis often the result. In recent years, researchers have increasingly turned to stem cell-based therapies as a potential method for repairing and replacing damaged nerve cells. They have struggled, however, to overcome numerous innate barriers, including myelin, a mixture of insulating proteins and lipids that helps speed impulses through adult nerve fibers but also inhibits neuronal growth.
Searching the entire genome, a Yale research team has identified a gene that when eliminated can spur regeneration of axons in nerve cells severed by spinal cord injury.
“For the first time, the limits on nerve fiber regeneration were studied in an unbiased way across nearly all genes,” said Stephen Strittmatter, the Vincent Coates Professor of Neurology and senior author of the study appearing April 10 in the journal Cell Reports. “We had no idea whether we knew a lot or a little about the mechanics of nerve cell regeneration.”
Researchers grew human spinal cord neurons from stem cells and injected them into healthy mice, where they successfully connected with other neurons.
Discovery could be key to treating brain and spinal cord injury
A foray into plant biology led one researcher to discover that a natural molecule can repair axons, the thread-like projections that carry electrical signals between cells. Axonal damage is the major culprit underlying disability in conditions such as spinal cord injury and stroke.
Andrew Kaplan, a PhD candidate at the Montreal Neurological Institute and Hospital of McGill University, was looking for a pharmacological approach to axon regeneration, with a focus on 14-3-3, a family of proteins with neuroprotective functions that have been under investigation in the laboratory of Dr. Alyson Fournier, professor of neurology and neurosurgery and senior author on the study.
New Hope for Paralyzed Patients?
If you have a spinal cord injury, recent reports on stem cell therapy look like a dream come true. Like wire spliced into a severed cable, stem cells could restore communication between your body and your brain.
After endless numbness, you might once again feel the grass between your toes or the caress of a lover. After an eternity of motionlessness, you might rise from your chair or hoist a glass of wine to your lips.
Role of adaptor protein CD2AP in neuron sprouting discovered by UofL researchers could lead to therapies for Alzheimer’s disease, stroke recovery and spinal cord injury
University of Louisville researchers have discovered that a protein previously known for its role in kidney function also plays a significant role in the nervous system. In an article featured in the April 13 issue of The Journal of Neuroscience, they show that the adaptor protein CD2AP is a key player in a type of neural growth known as collateral sprouting.
It’s a wonder of nature – and a darned good thing – that amid many billions of similar cells in the brain and spinal cord, neurons can extend their tendrillous axons to exactly the right place to form connections. Otherwise we wouldn’t move, sense or think properly, if at all. In a new study in the journal Science, researchers report a discovery that helps to explain how axons manage to find their way across the midline of the spinal cord.
The findings contribute toward solving the basic mystery of axon guidance, but they might also advance scientists a little closer to achieving the medical aspiration of repairing damage in the central nervous system.