Tag: Nervous System
Regimen of Epidural Spinal Cord Stimulation, Plus Extensive Locomotor Training, A Significant Breakthrough
A team of scientists at the University of Louisville, UCLA and the California Institute of Technology has achieved a significant breakthrough in its initial work with a paralyzed male volunteer at Louisville’s Frazier Rehab Institute. It is the result of 30 years of research to find potential clinical therapies for paralysis.
An article by Rob Stein on the front page of today’s Washington Post (May 20, 2011) announces a stunning breakthrough treatment for paralysis that has transformed the life of a man who was paralyzed in a car accident. The successful experimental treatment involves electrical stimulation of his damaged spinal cord through implanted electrodes. Scientists are still not exactly sure how it works, but it does. For one individual reading this article, this breakthrough was very old news—more than 27 years old.
Patrick Stroman’s work mapping the function and information processing of the spinal cord could improve treatment for spinal cord injuries.
“Basic physiology books describe the spinal cord as a relay system, but it’s part of the central nervous system and processes information just like parts of the brain do,” explains Dr. Stroman, director of the Queen’s MRI Facility and Canada Research Chair in Imaging Physics.
Dr. Stroman’s research is directed at precisely mapping the areas above and below a spinal cord injury in order to better determine the precise nature of an injury and the effectiveness of subsequent treatment. When medical research has advanced to a point where clinicians are able to bridge an injury on a spinal cord, Dr. Stroman’s spinal mapping technique will be key in accurately pinpointing the injury to be bridged.
Taxol stabilizes growing nerve cells and reduces the barrier-function of scar tissue
After a spinal cord injury a number of factors impede the regeneration of nerve cells. Two of the most important of these factors are the destabilization of the cytoskeleton and the development of scar tissue. While the former prevents regrowth of cells, the latter creates a barrier for severed nerve cells. Scientists of the Max Planck Institute of Neurobiology in Martinsried and their colleagues from the Kennedy Krieger Institute and University of Miami in the United States, and the University of Utrecht in the Netherlands, have now shown that the cancer drug Taxol reduces both regeneration obstacles. Science, January 27, 2011
Cutting-edge spinal cord research team eliminates critical bottlenecks
The Miami Project to Cure Paralysis, part of University of Miami, Florida, comprises a dedicated team of scientists who are researching a variety of treatment strategies for individuals with spinal cord injury. Dr. John Bixby and I head one of the Project’s laboratories, The Laboratory for Axon Growth and Guidance. At our laboratory, also known as the LemBix Laboratory, we conduct high-content screening (HCS) of neurons with the aim of finding new or improved treatments for spinal cord injury and other neurological disorders. HCS offers an ideal way to identify genes, molecular pathways and, ultimately, drugs that can promote the regeneration of central nervous system nerve cells.
The serious impact of the spinal cord injury is remembered during the second week of November by Australians with the help of Josh Wood’s inspiring story.
Online PR News – 19-November-2010 – Around Australia the second week in November is a time to reflect on the serious impact of Spinal Cord injury and Aussie Quadriplegic inspiration Josh Wood is being celebrated around the world for his efforts to educate. His story has taken Jack Canfield’s team (of Chicken Soup for the Soul fame) by the heart-strings and is published in the new version of that series ‘The Well Adjusted Soul’ released in Australia this month.
Newswise — The spleen, an organ that helps the body fight infections, might also be a source of the cells that end up doing more harm than good at the site of a spinal cord injury, new research suggests.
Considering the spleen’s role in the after-effects of spinal cord injury could change the way researchers pursue potential treatments for these devastating injuries.
Newswise — A study led by researchers in the Department of Neurosciences at the University of California, San Diego School of Medicine shows unexpected and extensive natural recovery after spinal cord injury in primates. The findings, to be published November 14 in the advance online edition of Nature Neuroscience, may one day lead to the development of new treatments for patients with spinal cord injuries.
While regeneration after severe brain and spinal cord injury is limited, milder injuries are often followed by good functional recovery.
The Michigan Spinal Cord Injury Association (MSCIA) has chosen to utilize donation money from their first major event to assist a woman in Detroit, who has not been able to leave her house in over a year except by ambulance to visit her doctor.
A patient paralysed through spinal cord injury has become the first person to receive human embryonic stem (ES) cell treatment in a clinical trial being conducted in the United States. The anonymous patient was injected with stem cells at the site of injury in the hope that the cells will repair the damaged nerve tissue to restore some movement.