Stem Cells Help Repair Paralysis in Mice; A Recipe for Humans?

Published: June 19, 2006  |  Source: bloomberg.com
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(Bloomberg) — Scientists have used embryonic stem cells to restore function in the legs of paralyzed mice, raising hopes they may some day achieve the same result in humans.

In the study, stem cells taken from mouse embryos were chemically transformed in a lab into Motor neurons, cells that carry impulses from the brain and spinal cord to receptors in the muscles. Researchers then injected the neurons into the mice in such a way that three in every four animals were able to bear weight on their hind legs and take steps after six months.

“This work is a remarkable advance that can help us understand how stem cells might be used to treat injuries and disease and begin to fulfill their great promise,” said Elias . Zerhouni, Director of the National Institutes of Health, in a statement. “The successful demonstration of Functional restoration is proof of the principle.”

The study, to be published in the Annals of Neurology next week, was funded in part by the NIH. It suggests similar techniques may eventually be useful for treating such disorders as spinal cord injury and Lou Gehrig’s Disease, also known as ALS, both of which leave people unable to use their limbs, the researchers said. They cautioned that such an advance in humans remains many years away.

The research used a cocktail of chemicals that help build nerves while inhibiting the body’s ability to protect itself from the new cells. The cocktail allows the motor neurons to re- connect, essentially re-establishing the circuitry that allows the body to signal muscles that they’re needed.

“This study provides a ‘recipe’ for using stem cells to reconnect the nervous system,” said study leader Douglas Kerr, of the Johns Hopkins University School of Medicine in Baltimore, Maryland, in a statement today. “It raises the notion that we can eventually achieve this in humans, although we have a long way to go.”

Rob Waters