Stem cell research activist, Dr. Wise Young, tackles current issues

Published: June 16, 2005  |  Source: sciwire.com
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Dr. Wise Young
Dr. Wise Young
DETROIT – (KRT) – Ten minutes after a recent announcement that South Korean scientists had discovered an efficient way to produce stem cells, the world’s largest spinal cord Web site carried the story.

“It’s unbelievable someone’s trolling the literature and posting it right away like that,” said Dr. Wise Young, administrator of www.sciwire.com.

Young, a Rutgers University neuroscientist, began the Web site in July 2001. He spends up to eight hours a day administering it, often signing off at 3 a.m., he said. He is both scientist and ombudsman to its 10,000 registered members.

A huge area of interest is cellular therapies abroad, particularly procedures in Portugal and China. They remain controversial because their results are largely unpublished. The therapies are costly, ranging from $20,000 to $50,000, and they hold risks. For now, Young’s site is one of the sources patients turn to for updates on how patients fare after the surgery.

Young, 55, born in Hong Kong and raised there and in Japan, was the late actor Christopher Reeve’s doctor. He helped lead a landmark 1990 study that became the standard of care for the immediate treatment of spinal cord injuries. It found that high-doses of methylprednisolone, a steroid drug, saved about 20 percent of Motor and sensory function when administered soon after a spinal cord injury.

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The study “was the beginning of my radicalization” because it took so long to convince medical centers to stock and administer the drug, Young said. Their reaction was like “cold water being thrown on my face.”

More recently, Young has been involved with a new drug, Fampridine-SR, or 4AP (which stands for 4-aminopyridine). It “helps boost the firing of neurons” after a spinal cord injury, he said. The drug – manufactured by Acorda Therapeutics – plugs potassium channels that leak into nearby nerve cells, causing them to short-circuit. Closing the channels lets the nerve cells transmit impulses again. Young is on the company’s board of directors.

He is married with two grown children and is professor and chair of the department of cell biology and neuroscience at Rutgers. He obtained his medical degree from Stanford University and his doctorate in physiology and biophysics from the University of Iowa.

Young was in Michigan in late April to address an all-day symposium sponsored by the University of Michigan.

The following are excerpts from a one-hour interview that followed his keynote speech:

Q: People are literally champing at the bit to find out when clinical trials with some of the stem cell therapies will begin in the United States. What kind of timetable do you envision?

A: Embryonic stem cells will take a while. There are two major problems that need to be solved with embryonic stem cells. One is we need very good screens (tests) to find the possibility of cancer. Those things are not yet available. I think this will produce a delay. The FDA (Food and Drug Administration) will want extensive safety data.

The problem is we haven’t had the cells to work with to collect that data. And even with the 22 cell lines we do have, the work is really slow. I’m expecting New Jersey and California to be putting resources into this. These resources (from states) already exceed the federal resources (in stem cell research). I’m hopeful we’ll see a picking up of the research that will solve that one major problem: getting an effective, reliable screening test.

All the so-called human embryonic stem cell groups are specializing in the study of existing stem cell lines. They are not creating new cell lines. So whatever clinical trial goes on, you need a center capable of producing new lines. There may be a dozen states with centers established. It will be two to three years before these centers are up and going and are well staffed.

Q: What do you think will happen in New Jersey?

A: We have a very strongly committed (acting) governor. Richard Codey has committed $150 million in state funds to build a stem cell research center. We’re also trying to get a referendum on the ballot for November to determine whether the state should issue bonds to finance grants for stem cell research. There may not be enough votes in the assembly to pass the referendum, so all the advocacy groups are clustering around Trenton.

The pro-life groups and the Catholic Church and a couple of other groups have basically seen New Jersey as the battleground where they draw the line. If New Jersey falls, they see all the other states doing the same. So they are pouring troops and money to stop the referendum. Politics is politics. It’s who speaks louder.

Q: You have expressed reservations about spinal autograft surgery in Portugal.

A: I’m just saying I’m not convinced any gains are from stem cells or OEG cells. The Lisbon team transplanted the patient’s own nasal mucosa into the spinal cord. It contains many cell types, including possibly stem cells and OEG cells, but it’s not clear that either of these cell types survive the transplantation or contribute to the recovery of patients.

kecklogo3It’s important to continue this research, and I support this research. I do have difficulty with two things, and I’ve said this publicly. I have difficulty with the fact that they take out a piece of spinal cord when they operate. That may cause more scar tissue. I asked Carlos (Dr. Carlos Lima, the spokesman for the Lisbon team): “Why do you take out a piece of the spinal cord?” And he says: “To remove scar tissue.” And I follow up and say: “How do you know it’s scar tissue?” He says: “We know.” He showed samples of tissue he removed, and there are axons in it. Axons are nerve fibers in the spinal cord that conduct impulses. The presence of axons in removed spinal cord samples suggests the team removed some nerve fibers from the spinal cord.

I think it’s OK to say we’re going to do this in complete patients, people who have no sensation below the injury. Those patients don’t have that much to lose. Another thing is we are not seeing the data from all his patients.

Q: Dr. Lima said in early May he has performed the surgery on 52 patients and that all have improved, though four developed temporary problems or loss of sensation.

A: He says they all have improved. But he doesn’t do the standard exam, and he’s not a spinal cord injury doctor. I’m aghast at the fact that he thinks he can remove parts of the spinal cord. I also asked him about deaths. He says there are none. I also have been told the neurosurgeon (Dr. Pratas Vital) doing the operation is very good. I respect that. But I’ve been urging everybody before they go to Portugal to ask these critical questions.

Q: You were Christopher Reeve’s doctor. You’ve mentioned how he taught you not to be afraid of using the word “cure.” How much did he contribute to your philosophy?

A: “Cure” isn’t a word that comes easily to a scientist. You don’t want to be promising something you can’t deliver. What Christopher convinced me about is that the main problem is hope. We don’t have hope. We have to overcome this hope barrier.

The new barrier is money. I’ve started to use the word billions. That’s what we need. People gasp when they hear it. We’ve set our sights so low that we would have been ecstatic if they gave us another $100 million. In the meantime, look at AIDS. George Bush, in the middle of the worst deficit, last year committed $10 billion to AIDS in Africa. It’s not like you can’t ask for it and you can’t get it.

Q: You are organizing a first international spinal cord symposium in Hong Kong. Tell me about it.

A: Yes, it will be held Dec. 17-20 in Hong Kong. We hope to invite 300 researchers and another 300 Chinese for a four-day meeting. At the end of the meeting, I’d hope we will have a ranking of our priorities.

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